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For example, phosphorylation of Sp1 and CREB in response to increased intracellular cAMP enhances their binding to the NAGS promoter, while liver-specific transcription factors hepatocyte nuclear factor 1 and nuclear factor Y respond to glucagon and glucocorticoid signals by synergizing with enhancer elements to upregulate NAGS expression, adapting to changes in nitrogen excretion under fasting or stress (17,18)

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Pickart and Margolina (2018, Cosmetics) reviewed GHK-Cu's role in stimulating collagen synthesis, activating matrix metalloproteinases, and promoting wound healing in vitro and in animal models