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Frontiers | Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy
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More recently, a family of potent and highly selective mechanism-based suicide substrate inhibitors were developed and shown to promote the irreversible inhibition of gut microbiota–dependent generation of TMA, suppression of host TMAO levels, and, in parallel, inhibition of platelet hyperresponsiveness and thrombosis potential in animal models (22)
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