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Challenging the view of glutathione as a protector in liver disease: https://t.co/JgWnzwmRwH Xiang-Yu Liu @XiangYuLiu7 C. Ronald Kahn @diabetesmaster & team @harvardmed show glutathione depletion in the liver surprisingly prevents fatty liver

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5-Amino-1MQ was identified as a potent NNMT inhibitor in work published by the Bhatt Lab and collaborators, with subsequent preclinical studies demonstrating that NNMT inhibition in diet-induced obese mice reduced body weight, decreased adipose tissue mass, and improved metabolic parameters including insulin sensitivity and plasma lipids