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semaglutide Semaglutide Drug Names : Ozempic ® (for T2DM) - injectable Wegovy ® (for weight management) - injectable Rybelsus ® (oral) - 1st oral GLP-1 agonist (FDA approved 9/20/19) Drug Category : GLP-1 receptor agonist, hypoglycemic Synthetic peptide analog of GLP-1 Mechanism of Action: Synthetic peptide that is chemically identical to GLP-1, except for three amino acid substitutions and modifications at positions 8, 26 & 34 (Figure 1) that prevent chemical breakdown by DPP-4, and increase binding to albumin