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Tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 17 (IL-17), interleukin 22 (IL-22), and granulocyte-monocyte colony-stimulating factor (GM-CSF) are present in the inflamed synovial tissue

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Concomitant medicines — particularly insulin or sulfonylureas — should be reviewed for interaction risk, and pregnancy or breastfeeding status should be assessed