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An independent 2019 systematic review by Gwyer, Wragg, and Wilson in Cell and Tissue Research — notably authored outside the original Zagreb research group — examined BPC-157 in musculoskeletal soft tissue healing and reported uniformly positive preclinical findings

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Notably, CRE sequences vary among genes, often exhibiting one or two base substitutions and even half-CRE sites (such as TGACG or CGTCA) can be recognized by ATFs, suggesting that while the core CRE motif is evolutionarily conserved, a certain degree of sequence flexibility is tolerated (103)