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The biological half-life of recombinant human Cu/Zn SOD (rhSOD) within the systemic circulation by liposomal encapsulation and aerosolization into the lungs of pigs leads to long-term and uniform uptake into systemic circulation without acute deleterious effects on respiratory tract suggesting that aerosolization of liposomal rhSOD could be a feasible strategy for administration of radical scavenging enzymes for treatment of systemic diseases [128]