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Studies in mice have shown that: ARA-290 can reduce macrophage activation and lessen the secretion of pro-inflammatory cytokines such as IL-6, IL-12, and TNF-α Reduced inflammatory signaling correlates with improved survival and function of transplanted islet cells Mechanistically, these effects are linked to ARA-290 binding to tissue-protective receptor complexes, leading to decreased apoptosis, enhanced tissue protection, and more favorable local immune profiles
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Owing to its location adjacent to the glomeruli and the presence of specific organic acid-base secretion systems, the proximal tubule is often exposed to higher concentrations of toxins compared to other nephron segments, making it the primary site of nephrotoxic damage [ 43 ]
