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There are many scaffold proteins that are associated along with c-MET receptor and leads to activation of downstream signal transduction pathways that include mitogen-activated protein kinase (MAPK) cascades, extracellular signal-regulated kinase 1 (ERK1) and ERK2, Jun amino-terminal kinases (JNKs) and p38, the phosphoinositide 3-kinaseβAkt (PI3KβAKT) axis, signal transducer and activator of transcription proteins (STATs), and the nuclear factor-ΞΊb inhibitor-Ξ± (iΞΊbΞ±)βnuclear factor-ΞΊb (NF-ΞΊb) complex [33]