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3 Molecular mechanisms of GPX4 in OA 3.1 Upstream regulation of GPX4: System Xc − –GSH axis and Nrf2 pathway 3.1.1 Critical role of System Xc − and GSH supply System Xc − is a heterodimeric membrane transport protein composed of a catalytic subunit, SLC7A11, and a regulatory subunit, SLC3A2, linked by a disulfide bridge
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After accumulation in certain tissues, they then induce a variety of adverse effects in various body systems, and when symptomatic, they are generally described as causing heavy metal-mediated toxicity